Thursday, December 9, 2010
EBV and XMRV - a new disease model
An unpublished Spanish study reveals what could possibly unlock the mysteries of CFS. EBV is a common herpesvirus that almost 95% of the population carries by adulthood according to the CDC, however it seldom produces disease. In a percentage of the population it causes infectious mononucleosis, but afterwards remains dormant in immune system cells. It brings the question - Could EBV or another herpesvirus be the key that unlocks the door for XMRV - quite possibly. Once XMRV enters a cell, it could quite conceivably create an immune dysfunction that allows EBV to reactivate at a low level, fuelling a vicious cycle - through EBV producing a gene that downregulates APOBEC3, somewhat like the HIV vif protein does.